The cast includes Devon Aoki, John Ventimiglia, Kris Lemche, Ralph Macchio, Jeremy Sisto and Waris Ahluwalia.

Julian Marsh (Jake Hoffman), an unemployed young lothario, is forced by his doctor dad (Chip Zien) to accept a job directing an off-Broadway play called Rosencrantz and Guildenstern Are Undead, which is described as a weird adaptation of Hamlet.

The play has been written by a mysterious, pallid Romanian named Theo Horace (John Ventimiglia), a vampire who has just killed a young woman (Bijou Phillips).

Unaware of the danger that surrounds Theo's play, Julian casts his best friend Vince (Kris Lemche) as Hamlet and uses his new job to impress his ex-girlfriend, Anna (Devon Aoki), an aspiring actress.

Two bumbling New York City detectives (Jeremy Sisto and Lou Carbonneau) chase suspects as the movie builds to its climactic sequence.

Its basic plot points are that Hamlet's friend Horatio (played by Theo) is a master vampire, over 2000 years old, who had once lived in ancient Rome.

Galland, along with his editor, Connor Kalista, and cinematographer, Chris Lavasseur, presented their experience with the Red One at a content panel ("Case Study: Rosencrantz and Guildenstern Are Undead") at the National Association of Broadcasters convention (NABShow 2008), on April 15, 2008.