After passing through Tarija as a parkway, the road continues, running west over the mountains to the rest of the city and meeting Route 20 in El Puente.

Here, the highway bears north again, running through the Rio San Pedro.

Bearing West again, the road intersects National Route 14, and then enters Potosi.

Near El Alto International Airport, the road turns at a cloverleaf interchange, running west.

Intersecting Route 2, the highway leaves the suburbs, and runs 95 km to Desaguadero.