After I-29 and 35, 210 immediately intersects Route 1 and continues east.

It intersects Walker Road in front of NKC Hospital and the Cerner world headquarters before an interchange with Chouteau Trafficway near North Kansas City, Missouri.

It becomes a limited access freeway as it exits North Kansas City and into Kansas City proper.

There are interchanges with North Brighton Avenue and Northeast Searcy Creek Parkway before it intersects I-435.

Here, it reverts to a four-lane road with stoplights.