Route nationale 2 (RN2) is a highway in French Guiana, an overseas region and department of France in South America.

The highway connects Cayenne with Saint-Georges and has a total length of 185 kilometres (115 mi).

[1] The highway provides a direct connection to Brazil via the Oyapock River Bridge.

The highway starts in Balata, a suburb of Cayenne, at an intersection with Route nationale 1.

[6] Traffic volume on Route nationale 2 varies significantly.