The Rue Mouffetard (French pronunciation: [ʁy muftaʁ]) is a street in the 5th arrondissement of Paris, France.

It is closed to normal motor traffic much of the week, and is predominantly a pedestrian street.

6 rue Mouffetard in April 1746, where lived also François-Jacques Guillotte, a police officer who wrote an article (Pont militaire) for the Encyclopédie by Diderot.

The area remained relatively unchanged because of its location on the Montagne Sainte-Geneviève, which protected it from Baron Haussmann's redevelopment during the reign of Napoleon III.

The Ecole de Paris painter, Isaac Frenkel Frenel, lived in the street from the 1950s until his death in 1981.