The son of a freedman, Rufio arrived in 48 BC as a member of Caesar's army in Egypt.
After Caesar intervened in the Ptolemaic struggle for the throne between the siblings Cleopatra VII and Ptolemy XIII and won the Alexandrian war against Ptolemy XIII and his allies (January 47 BC), he stationed three legions in Egypt after placing Cleopatra on the Egyptian throne.
[1] These troops served to protect but also keep in check the rule of Cleopatra, who despite being Caesar's mistress was not fully trusted by the Romans.
The main reason for this nomination was Caesar's fear that an influential senator, left behind in Egypt as commander-in-chief, could use the economically strong and strategically important land on the Nile as a base to make a bid for power.
[2] Rufio, being not of noble birth, could never amass the connections or wealth needed to threaten Caesar.