São Luíz do Norte is a municipality in northeastern Goiás state, Brazil.

An alternative spelling is "São Luís do Norte".

Neighboring municipalities: Hidrolina, Santa Rita do Novo Destino, Goianésia, Santa Isabel, Nova Glória and Itapaci.

The economy is based on subsistence agriculture, cattle raising, services, public administration, and small transformation industries.

The adult literacy rate was 80.5% (2000) (national average was 86.4%).