S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation.

S100 genes include at least 13 members which are located as a cluster on chromosome 1q21.

This protein has the highest content of cysteines of all S100 proteins, has a high affinity for Zinc, and is highly expressed in human hair cuticle.

The precise function of this protein is unknown.

[6] This article on a gene on human chromosome 1 is a stub.