4GA7199266222ENSG00000021355ENSMUSG00000044734P30740Q9D154NM_030666NM_025429NP_109591NP_079705Leukocyte elastase inhibitor (LEI) also known as serpin B1 is a protein that in humans is encoded by the SERPINB1 gene.

SerpinB1 was found to reduce tissue damage caused by the mentioned proteases during inflammation and has a role in neutrophil homeostasis in mice.

In various infection models (e.g. pneumonia) correlation of SerpinB1 absence and lack of microbial clearance have been shown.

Different knockout strains serve as model to investigate the role of SerpinB1 in vivo.

[8][9][10] This article incorporates text from the United States National Library of Medicine, which is in the public domain.