The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily.

SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes.

This protein was also reported to participate in the recruitment of tyrosine kinase SYK.

Alternatively spliced transcript variants have been found for this gene.

[8][9] This article incorporates text from the United States National Library of Medicine, which is in the public domain.