[8][10] SON protein is essential for maintaining the subnuclear organization of the factors that are processed in the nucleus highlighting its direct role in pre-mRNA splicing.

The controlled process of splicing takes place in the spliceosome, a complex that brings together pre-mRNA and a variety of binding proteins.

Not only the SON protein interferes in the splicing but also makes complex mechanisms such as the RNA post-transcriptional to cooperate with the splicing-mRNA processing.

[14] On the one hand, SON protein is required to maintain the genome stability in order to ensure an efficient RNA processing of affected genes.

It also facilitates the interaction of SR proteins with RNA polymerase II and is required for processing of weak constitutive splice sites, having also strong implications in cancer and other human diseases.

[7][10] On the other side, a deficiency or knockdown of SON protein causes various and severe defects in mitotic division arrangement, chromosome alignment and microtubule dynamics when spindle pole separation takes place.

Specifically, these results revealed that the serine-arginine-rich protein involved in the RNA splicing process, could suppress pancreatic cell tumorigenicity.

Although the SON gene is recognized for its engagement in diverse cellular processes like mRNA splicing, DNA repair, and cell cycle regulation, its precise involvement in the host's response to viral infections and its therapeutic applications remain ambiguous[16]).

This pursuit aims to enhance our comprehension of the dynamics between viruses and hosts, with the potential to unveil novel targets for therapeutic interventions.

In the event that SON is identified as a contributor to either promoting or inhibiting viral replication, there is potential for exploring genetic or epigenetic strategies.