3SYX161742114715ENSG00000166068ENSMUSG00000027351Q7Z699Q924S8NM_152594NM_001277256NM_033524NP_689807NP_001264185NP_277059Sprouty-related, EVH1 domain-containing protein 1 (pronounced spread-1) is a protein that in humans is encoded by the SPRED1 gene located on chromosome 15q13.2 and has seven coding exons.

[5] SPRED-1 is a member of the Sprouty family of proteins and is phosphorylated by tyrosine kinase in response to several growth factors.

The encoded protein can act as a homodimer or as a heterodimer with SPRED2 to regulate activation of the MAP kinase cascade.

[5] Defects in this gene are a cause of neurofibromatosis type 1-like syndrome (NFLS).

[5] Mutations in this gene are associated with The following mutations have been observed: SPRED1 gene variant database This article incorporates text from the United States National Library of Medicine, which is in the public domain.