It runs northeast as a four-lane divided highway, until encountering Swindell Road at the Lakeland Mi Pueblo Flea Market, where it turns straight east.

Another route that US 92/SR 546 has direct access with is the northern terminus of Florida State Road 563 at Martin Luther King Jr. Avenue.

Three blocks later, the route encounters the intersection with the southern terminus of Florida State Road 33 at Massachusetts Avenue where it becomes a four-lane divided boulevard again.

At North Gary Road the route becomes a four-lane undivided highway, then passes the site of the former community of Acton.

East of there on the opposite side is the Lake Parker Boat Ramp in Sertoma Park, which also contains a historical marker for the Blue Star Memorial Highway, The road becomes a divided highway again, just before its eastern terminus at East Gary Road, which is also hidden SR 600.

US 92 continues along SR 600 through the rest of its journey into Lake Alfred, Kissimmee, Orlando, Sanford, DeLand and Daytona Beach.