Most episodes center on the typical issues along with those that emanated from Sabrina's inexperience with or misuse of several magic, witchcraft and extremely powerful and complex spells.

Sabrina and her best friend Chloe Flan would often use magic (often from the "Spooky Jar": a cookie jar containing a green genie-like being in the family's kitchen) for all types of perceived emergencies, ranging from trying to fit into skinny new clothes to turning Sabrina's crush Harvey into a superhero.

Celebrity voice cameos in this series included Mr. T, Long John Baldry and "Weird Al" Yankovic.

Melissa instead voiced Sabrina's two aunts, Hilda and Zelda, originally played on the live-action series by Beth Broderick and Caroline Rhea, respectively.

On September 19, 2009, the series returned to CBS, this time as part of the network's Cookie Jar TV cartoon lineup, until 2010, being replaced with Sabrina's Secret Life.

The package was pre-sold to TF1 in France, RTÉ in Ireland, Mediaset in Italy, ORF in Austria, Alter Channel in Greece, FORTA in Spain, SBT in Brazil, Teletoon in Canada, Super RTL in Germany, Noga Communications in Israel and Saran in Turkey, in addition to Disney Channel and Toon Disney networks in the United Kingdom, Asia, Taiwan, Australia, France, Latin America, Brazil, the Middle East and Spain.

[9] In the Philippines, Viva Video and Cookie Jar Entertainment released a few DVD sets in the countries.

Storylines focus on the trials and tribulations of being a tween: friendships, school assignments, and dealing with increasing responsibility.

[15] Several other small plastic toys, including a few figurines and a Polly Pocket-esque Sabrina doll were sold in stores while the series was in production.

[16] On August 17, 2000, Simon & Schuster Interactive's Knowledge Adventure and Havas Interactive officially announced the video game Sabrina The Animated Series: Magical Adventure for the Microsoft Windows and Macintosh computer systems.

The series was planned to have 52 half-hour episodes, each budgeted at $275,000 to $325,000, and would air in the Fall of 2001, with DIC holding all worldwide distribution rights.

[20] The series would have focused on Salem's attempts to become a warlock again by proceeding to do enough good deeds, but lets his attitude and wit get the better of him.