Saesi Tsaedaemba (Tigrinya: ሳዕሲዕ ጻዕዳ እምባ; also transliterated as Saʿsi Ṣaʿda ʾƎmba[1]) is one of woredas in the Tigray Region of Ethiopia.

Located in the Misraqawi Zone at the eastern edge of the Ethiopian highlands, Saesi Tsaedaemba is bordered on the south by Kilte Awulaelo, on the southwest by Hawzen, on the west by Ganta Afeshum, on the northwest by Gulomahda, on the north by Irob, on the east by the Afar Region, and on the southeast by Atsbi Wenberta.

Towns in Saesi Tsaedaemba include Edaga Hamus and Freweyni also known as Sinkata) where the woreda office is located .

[2] Near Edaga Hamus not only can one find the monolithic church of Gebriel Tsilalmao, but also nearby is a stelae similar to those found in Axum only smaller, in the cemetery of the church of Maryam Tehot (a modern structure built on the foundations of an older building); the monument's date is unknown, but presumed pre-Christian.

Saesi Tsaedaemba was one of nine woredas in Tigray most affected by a drought during 2008, requiring emergency food supplies to be requested for an estimated 600,000 people.

Eritrean soldiers killed approximately 150 civilians, including a priest and women seeking refuge in a church, located 4 km to the west of Marieam Dengelat.