A member of the Most Beautiful Villages of Quebec, Saint-Antoine-de-Tilly has been colonized since the early beginnings of New France.

In 1672, The territory of Saint-Antoine-de-Tilly was given to a lieutenant of the Carignan regiment, Claude-Sébastien de Villieu, by the intendant Jean Talon.

Later, The territory was sold to Pierre-Noël Le Gardeur, sieur de Tilly.

Under is ownership, in 1702, a parish was canonically erected and the territory took the name Saint-Antoine-de-Tilly.

In 1909, it lost a small section of its territory for the creation of Notre-Dame-du-Sacré-Cœur-d’Issoudun.