Sainte-Croix (French pronunciation: [sɛ̃t kʁwa] ⓘ) is a municipality in and the seat of Lotbinière Regional County Municipali in Quebec, Canada.

[4] It was granted on January 16, 1637, by the Compagnie des Cent-Associés, under Henri de Lévis.

Father Jérôme Lalemant took symbolic possession of the seigneury on 14 September 1647 on their behalf.

The first settlers arrived around 1680, including the family of Louis Houde on 13 February 1682, who was then living on the Île d'Orléans.

In 1846, Pierre-Gustave Joly, seigneur of the seigneury of Lotbinière, purchased part of the land of Pointe-Platon from the Ursulines, a point of land bordering the seigneuries of Lotbinière and Sainte-Croix on the St. Lawrence River.