Saint Kitts and Nevis competed at the 2021 Junior Pan American Games in Cali–Valle, Colombia from November 29 to December 2, 2021.

[1][2] The Saint Kitts and Nevis team of three athletes (one male and two females) who competed in two sports - athletics (track and field) and tennis[3] - was officially named on November 19, 2021.

The following is the list of number of competitors (per gender) who participated at the games per sport/discipline.

Saint Kitts and Nevis qualified two track and field athletes (one male and one female).

[4][3] Saint Kitts and Nevis qualified one female tennis athlete.