Saint Louis Creek is a tributary of the Fraser River in Grand County, Colorado.

The creek rises near Saint Louis Peak in the Arapaho National Forest.

[2] Former United States President Dwight D. Eisenhower used to vacation with friends at the Byers Peak Ranch southwest of Fraser.

Saint Louis Creek flows through the ranch, and Eisenhower used to fish for brook trout in the creek during his visits.

[3] While recuperating from his heart attack in fall 1955, Eisenhower completed a painting of the creek, frozen over in winter.