is a private Diocesan Catholic school located at Cando Street, Poblacion, San Antonio, Nueva Ecija, Philippines.

It was the same year when Bishop Vicente P. Reyes of Cabanatuan requested the Provincial Sisters of St. Paul of Chartres (SPC) to manage the school.

The four SPC sisters: Sr. Caritas de St. Paul Sevilla, Sr. Mary Asella Cariaga, Sr. Marie Edissa Conel and Sr. Jeanne de Rossaire Marquez left St. Paul College of Manila to open the first Catholic school in San Antonio.

Pedro Balagtas who was then the parish priest of San Antonio had collaboration in preparing the necessary papers and facilities for that school year.

It was during the term of Sr. Lutgard of the Sacred Heart Ramirez, SPC, that St. Paul School of San Antonio enrollment increased yearly.

All school employees, teaching and non-teaching staff were given specific job description for a very proficient performance of their tasks.

Michael Feliciano I. Veneracion officiated at the Holy Mass and introduced to the school community the newly appointed director and principal Rev.

Felipe L. Dayao, Jr.[1][full citation needed] His service to the academe was terminated when he died on March 28, 2013, due to Cardiac Arrest.

However, in June 2014, Mrs. Jovita P. Villas was appointed by Bishop Sofronio Bancud, SSS, DD as the new directress of the school up to this date.