[1][2][3][4][5] According to traditional accounts, in 1489, after the fall of the Byzantine Empire, the relics of St. Spyridon and St. Theodora,[6] were brought to Corfu from Constantinople by Greek monk Georgios Kalochairetis, who was also a person of wealth, and were kept as property of his family.

[2] The lack of any underground chamber to house the remains of the saint was part of a deliberate design plan to make them as accessible as possible.

[4][5] Above the western door of the narthex the imperial coat of arms of the House of Romanov stands as a reminder that the church was under the nominal protection of Russia from 1807-1917.

The inscription on the lamp reads as follows: OB SERVATAM CORCYRAM DIVO SPVRIDIONI TVTELARI SENATVS VENETVS ANNO MDCCXVIWhich translates as: "For the Salvation of Corfu, to the Patron Saint Spyridon, the Senate of Venice, 1716 AD".

[5] The largest lamp in the church is found near the pulpit and was offered to the saint by the Venetian High Admiral Andrea Pisani and the rest of the Venetian leaders with the inscription: DIVO SPVRIDIONI TVTELARI VTRAQVE CLASSE PROTECTA ANDREA PISANI SVPREMO DVCE VTRIVSQVE CLASSIS NOBILES EX VOTO ANNO MDCCXVIIWhich translates: "To the Patron Saint Spyridon for having protected the two fleets under the leadership of Andrea Pisani, Commander in Chief of both fleets, the nobles in votive offering, AD 1717".