The Sainte-Marie River (French: Rivière Sainte-Marie) is a tributary of the Gulf of St. Lawrence, flowing in the municipality of L'Île-d'Anticosti, in the Minganie Regional County Municipality, in the administrative region of Côte-Nord, in province of Quebec, in Canada.

The "Rivière-Sainte-Marie" sports camp was built during the 20th century, west of the mouth of this stream.

The main forest road (east-west) of Anticosti Island serves the upper part of this valley.

[1] The Sainte-Marie river draws its source from Lake Sainte-Marie (length: 0.7 km (0.43 mi) almost round in shape; altitude: 61 m (200 ft)) located in the central-western part of the Anticosti Island.

[2] The Commission de toponymie du Québec believes that this toponym was originally attributed by the explorer Louis Jolliet, who had become the owner of the island since 1680; he would have designated it in honor of his eldest daughter Marie-Charlotte.