The Spanish word arroyo means "stream" or "brook", but the Saladillo is a sizable river with a drainage basin encompassing 3,205 square kilometres (1,237 sq mi).
[2] Its water services an important area in the southern part of Santa Fe province—both economically for agriculture, and demographically, since its last few kilometres flow through inside a densely populated area (Rosario has over a million residents).
The port of Villa Gobernador Gálvez is located on the mouth of the Saladillo.
It requires periodic dredging to support its massive use for agriculture, which in turn degrades the water quality with pollutants such as pesticides and fertilizers, and tends to fill the river with sediments produced by erosion.
The lower course is an urban stream, and is polluted by industrial and domestic waste.