Home games are played at Carilion Clinic Field at Salem Memorial Ballpark, a 6,300-seat facility opened in 1995.

Prior to adopting the Red Sox name in 2009, the team was known as the Salem Avalanche from 1995 through 2008, when it was affiliated with the Colorado Rockies (1995–2002) and Houston Astros (2003–2008).

The franchise was owned from 1986 until 2006 by Kelvin Bowles, a cable television executive and scout in Major League Baseball.

Bowles, who scouted for the Boston Red Sox from 2002 to 2005, bought the team when it was in danger of moving from Salem.

[9] On the 17th of March 2023, it was announced that their owners, FSG, sold them to Diamond Baseball Holdings who also own the Red Sox Double-A affiliate, the Portland Sea Dogs.

The connection with neighboring Roanoke was emphasized during the 2017 Carolina League All-Star Classic, hosted by Salem, that was represented by a logo featuring the iconic Mill Mountain Star.

Salem is also located in the Blue Ridge Mountains, which are featured prominently on the team's logo and are clearly visible over Carilion Clinic Field's outfield walls.

This mountain view includes the aforementioned star, visible on clear nights over the left field wall.

The Red Sox share their stadium with the NCAA Division III Roanoke Maroons and have previously hosted the "Hokie-Smokey Classic" baseball series between the Tennessee Volunteers and the nearby Virginia Tech Hokies.

According to the team's website, Mugsy descended from the passing Hale-Bopp comet that raced across the Roanoke Valley sky on April 4, 1997.

Lacking a cute or friendly appearance, the mascot intimidated children and was an object of derision by adult fans.