Saline Creek is a stream in northern Miller County in the U.S. state of Missouri.
The stream parallels Missouri Route M as it enters the Saline Valley Conservation Area.
The stream remains within the conservation area for about six miles and crosses under Missouri Route 17 just prior to its confluence with the Osage (at 38°16′19″N 92°24′47″W / 38.27194°N 92.41306°W / 38.27194; -92.41306[1]) about three miles northeast (downstream) of Tuscumbia.
[3] Saline Creek most likely was so named on account of mineral licks near its course.
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