[4] This is partially due to the damage Perez's knees sustained after playing catcher professionally almost every game for over a decade.

[5] Pérez holds the single-season MLB record for most home runs as a primary catcher with 48, surpassing Johnny Bench, who hit 45 during the 1970 season.

[7] To keep her only child busy, Yilda enrolled him in a baseball school in Valencia, where he showed an ability to throw, catch, and hit balls as young as age six.

In 2010, Pérez was promoted to the High-A Wilmington Blue Rocks and also played for the Surprise Rafters in the Arizona Fall League.

[10] In 2011, Pérez was promoted again, starting the year with the Double-A Northwest Arkansas Naturals before playing 11 games for the Triple-A Omaha Storm Chasers in July and August.

[7] On August 29, Pérez hit his first major league home run off Max Scherzer of the Detroit Tigers.

On February 27, Pérez signed a five-year, $7 million extension that included three club options and placed him under team control through 2019.

[15] While catching a bullpen session before a spring training game in 2012, Pérez tore the meniscus in his left knee.

In the 2014 American League Wild Card Game, Pérez singled down the left field line in the bottom of the 12th inning, driving in the winning run as the Royals beat the Oakland Athletics 9–8.

[26] Perez was named to his fifth consecutive All-Star Game as the starting catcher for the American League along with teammate Eric Hosmer.

[28] Pérez hit his first career grand slam on June 21, helping the Royals to a 6-4 come-from-behind win against the Boston Red Sox.

On March 28, Pérez suffered a grade 2 tear of the medial collateral ligament in his left knee while carrying a suitcase up a flight of stairs.

[34] On September 14, Perez hit his second grand slam of the season in the bottom of the ninth inning against the Minnesota Twins, breaking a 4–4 tie.

[39] On March 6, the team announced that Perez had undergone Tommy John surgery to repair the tear and would miss the entire 2019 season.

[43][44] On March 21, Pérez agreed to a four-year, $82 million contract extension with the Royals that would keep him in Kansas City through the 2025 season.

[45] On April 21, Pérez hit a walk-off single in the bottom of the ninth inning to beat the Tampa Bay Rays 9–8.

[54] Pérez finished the season batting .273/.316/.544 with 48 home runs and a league-leading 121 RBIs, winning his fourth Silver Slugger award.

[55] His 48 home runs tied Vladimir Guerrero Jr. of the Toronto Blue Jays for the most in MLB, giving Pérez two-thirds of the batting Triple Crown.

He ranked first among all qualified American League catchers (minimum 50% games at catcher) in RBIs, on-base percentage, slugging percentage, on-base plus slugging, and extra-base hits, second in batting average and hits, and third in home runs, while winning his fifth Silver Slugger award.

[66] In the offseason, Pérez resides in his hometown with his wife, Maria Gabriela, sons Salvador Jr. and Johan, and daughter, Paulina.

[68] Near the end of the 2013 season, teammate Alcides Escobar sprayed Pérez with Victoria's Secret women's perfume and told him he would get four hits, a prediction that came true.

[70] Pérez continued to wear perfume during games as a good-luck charm, switching to 212 VIP cologne by Carolina Herrera in 2014[71] and later Invictus by Paco Rabanne.

In the 2014 and 2015 seasons, Pérez made a habit of playfully pestering teammate Lorenzo Cain by taking videos of him and posting them on Instagram.