Playing for the school's baseball team, he had a 7–3 win–loss record and a 1.77 earned run average (ERA) with 117 strikeouts and 29 walks with 25 hits allowed in 59+1⁄3 innings pitched in his sophomore year.

[1] While in his junior year, he competed in the American Amateur Baseball Congress and won the 2006 Connie Mack World Series.

[4] Solis was also a dual sport athlete playing the varsity football team alongside Minnesota Vikings defensive end Everson Griffen.

[1] The Arizona Diamondbacks selected Solís in the 18th round of the draft, but he did not sign in order to play college baseball.

[5][6][7] Expected to pitch more in 2009 due to San Diego teammate Brian Matusz signing a professional contract, Solís instead injured his back while weightlifting.

[12] He was shut down in June 2014 with discomfort in his elbow after making one start for the Harrisburg Senators of the Class AA Eastern League.

[8] Solís started the 2016 season at Triple-A Syracuse, but he was called up April 27 after reliever Matt Belisle was injured and placed on the disabled list.

[18] Solís was regarded as having what an SB Nation writer called "something of a breakout season" in 2016, pitching to a 2.41 ERA in 41 innings and proving equally effective against hitters on both sides of the plate.

[24] He had difficulty against left-handed batters during the year; they had a .993 on-base plus slugging percentage in 88 match-ups against him, hitting five home runs, two doubles, and two triples.

[24] Solís was scheduled to reach non-tender free agency on November 30, 2018, but the Nationals avoided that by signing him to a one-year deal that day,[24][26] partly because his success against left-handed batters prior to 2018 suggested that he might again succeed against them in the future.

When he was in high school, his family opened an orphanage in South Africa for children who lost their parents to the AIDS epidemic.