He played college football for the Hawaii Rainbow Warriors and was selected in the second round of the 2007 NFL draft by the Miami Dolphins.

Satele attended Kailua High School in Hawaii where he was a First-team All-State Offensive lineman as a senior.

The final 13 starts of his redshirt freshman season were at Left guard, as he earned Second-team All-Conference honors.

In the 2009 offseason, the Dolphins signed free agent center Jake Grove, prompting speculation Satele could move to right guard.

Although Satele was demoted at the beginning of the 2010 NFL season in favor of rookie Jared Veldheer, that lasted only one game.

On opening day of the 2011 NFL season, Satele played between Carlisle and a new left guard, rookie Stefen Wisniewski, helping Darren McFadden and others rush for 190 yards in a win against the Denver Broncos.

On March 21, 2012, Satele signed with the Indianapolis Colts to replace long-time incumbent Jeff Saturday at center.

[8] On August 2, 2014, Satele re-signed with the Dolphins after starting center Mike Pouncey underwent surgery.