Samsula-Spruce Creek is a census-designated place (CDP) in Volusia County, Florida, United States.

[3] While many households reside here, it is principally an agricultural area west of the cities of Port Orange and New Smyrna Beach.

[5] At the 2000 census,[2] there were 4,877 people, 1,953 households and 1,511 families residing in the CDP.

21.1% were of German, 17.1% English, 9.1% Irish, 7.8% American and 6.1% Italian ancestry according to Census 2000.

16.7% of all households were made up of individuals, and 6.5% had someone living alone who was 65 years of age or older.