[1] After his arrival, he became one of Tucson's leading citizens and the brother-in-law and business partner to Arizona Territorial delegate Hiram S. Stevens.
[2] While Hughes' formal education consisted of three days of school room instruction, he learned a variety of skills while working.
[4] His early employment included positions as a factory worker, canal boat pilot, and apprentice baker before becoming a cabin boy on a steamboat in 1848.
Two years later, working as a cook to pay his way, Hughes traveled from St. Joseph, Missouri, to Hangtown, California.
[2] In California, Hughes worked as a stagecoach stop operator, hotel keeper, restaurant owner, and miner.
[1] The advanced stage of his medical problems forced him to stop in both Yuma and Maricopa Wells, New Mexico Territory for several days rest before reaching Tucson on March 12, 1858.
[6][7] When the American Civil War reached Tucson, the Confederacy gave Hughes and other supporters of the Union cause the option to leave or be shot.
[10] That same year he was allegedly involved with the Camp Grant Massacre, supposedly providing supplies to the assailants but not participating in the attack itself.