The Samuel May House is a Federal style residence located at 690 North Lake Drive in Prestonsburg, Kentucky.

Relatives still living include Jack May, Vince May, Treasa May, Kim May, Eric May, Kevin May, Tonia May, Lisa May.

From 1817 to 1821, May acquired 3,000 acres (12 km2) of land along the banks of the Levisa Fork, where he developed a farm and set up a mill.

This unusual building technique not only created deep window sills and door frames, but helped preserve the structure over the generations.

[2] The dream of renovating the historic home and developing it into a living history museum began in March 1993 with the creation of the Friends of the Samuel May House, Inc.[4] Due to a lack of funds very few tasks could be completed.