Sharp appears to have spent a part of his apprenticeship in France, where he made the acquaintance of Voltaire, and acquired a knowledge of French surgery which afterwards stood him in good stead.
He was elected surgeon to Guy's Hospital on 9 August 1733, the year in which Cheselden published his ‘Osteographia,’ (or anatomy of bones).
Out of these lectures grew Hunter's Great Windmill Street school of medicine, which laid the foundations of modern medical teaching.
[2] Sharp resigned his appointment at Guy's Hospital on 23 September 1757 on the ground of ill-health; but he continued to practise until 1765, when he set out on a winter tour through Italy.
Besides the Letters from Italy, Sharp published: To the Philosophical Transactions Sharp contributed two papers in 1753 on ‘A New Method of Opening the Cornea in order to Extract the Crystalline Humour,’ and in 1754 a paper ‘On the Styptic Powers of Agaric.’ In addition, he reviewed the surgical portion of James Greive's translation of 'A.