A trephine (/trɪˈfaɪn/; from Greek τρύπανον, trypanon 'instrument for boring')[2] is a surgical instrument with a cylindrical blade.
It can be of one of several dimensions and designs depending on what it is meant to be used for.
They may be specially designed for obtaining a cylindrically shaped core of bone that can be used for tests and bone studies, cutting holes in bones (e.g., the skull) or for cutting out a round piece of the cornea for eye surgery.
A cylindrically shaped core of bone (or bone biopsy) obtained with a bone marrow trephine is usually examined in the histopathology department of a hospital under a microscope.
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