San Antonio Huitepec is a town and municipality in Oaxaca in southeastern Mexico and is the fastest shrinking municipality in Oaxaca in terms of population, with a population change of -31.5% going from the 2010 consensus to the 2020 consensus.

The municipality covers an area of 199.04 km2.

It is part of the Zaachila District in the west of the Valles Centrales Region As of 2005, the municipality had a total population of 4,303.

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