San Carlos Centro is a city in the center of the province of Santa Fe, Argentina, located 46 kilometres (29 mi) from the provincial capital Santa Fe.

Like most other towns in the Las Colonias Department, San Carlos Centro was originally an agricultural colony, populated by European immigrants.

It was founded in 1858 by Carlos Beck Bernard, of the Beck & Herzog Swiss Colonizing Society.

The settlement received the category of comuna (village or commune) on 2 June 1886, and became a city (full-fledged municipality) on 9 October 1986.

This article about a place in Santa Fe Province, Argentina is a stub.