San Colombano al Lambro (Lodigiano: San Culumban al Lamber) is a comune (municipality) in the Metropolitan City of Milan, in the Italian region of Lombardy, located about 40 kilometres (25 mi) southeast of Milan.

San Colombano al Lambro borders the following municipalities: Borghetto Lodigiano, Graffignana, Livraga, Miradolo Terme, Orio Litta, and Chignolo Po, none of which are in the Metropolitan City of Milan.

All grapes destined for DOC wine production need to be harvested to a yield no greater than 11 tonnes/ha.

The finished wine must attain a minimum alcohol level of 11% in order to be labelled with the San Colombano DOC designation.

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