San Cristóbal is a city in the center-north of the province of Santa Fe, Argentina, 179 km north-northwest from the provincial capital.

It had about 14,000 inhabitants at the 2010 census [INDEC] and it is the head town of the San Cristóbal Department.

The town was founded in 1890 and the attained the status of comuna (commune) on 1894-01-21.

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