San Domenico is a Roman Catholic basilica church, located on Piazza Giordano Bruno and via del Castellano in the city of Perugia, region of Umbria, central Italy.

A church, titled the Pieve di Santo Stefano del Castellare, was present at the site since about the 5th century.

The bell tower, constructed between 1464 and 1500 by the Lombard architect Gasperino di Antonio, originally stood at a remarkable height of 126 meters, but it was later reduced for stability reasons.

It still contains the 14th-century funerary monument to Pope Benedict XI, who died at Perugia in 1304 (perhaps sculpted by a pupil of Arnolfo di Cambio[2]).

It still has the altar (1459) of the Chapel of the Rosary by Agostino di Duccio and wooden choir-stalls, dating to the late 14th century.