San Francesco is a Gothic-style, Roman Catholic, Franciscan church in Cagli, province of Pesaro e Urbino, region of Marche, Italy.

The lunette above has a much repainted fresco of the Madonna del Soccorso with Saints Francis and John the Baptist, attributed to Guido Palmerucci.

On the side altars the principal works (counterclockwise from the right) are: paintings by Gaetano Lapis (1730); a processional wooden crucifix (after 1750) from the Northern European school.

The lateral walls has canvases depicting an Enthroned Madonna and Child with the Magdalen, and Saints Chlare and Monica, Ludovico, and Anthony of Padua (1529) by Francesco Battaglini.

The first altar on the left houses an altarpiece depicting Madonna and Child with Saints Roch, Francis, Geronzio, Stefano e Sebastiano (1540) by Raffaellino del Colle.