In 1645, the mission was destroyed by the local Conchos Indians; they drove away the Spanish settlers and killed the missionaries Thomas & Zigarán and Francisco Labado.

In 1677, the settlement was re-established and repopulated by Sierra Lopez y Osorio, governor of Nueva Vizcaya, with the new name of San Francisco de Cochos.

Other common plants in the northern part of the territory include shrubs such as shack or rib cow, mariola or guayule, and the sweet mesquite.

Similarly there are succulents, cacti and some small to medium, such as the cholla, palmitas or yuccas, agaves and such as lechuguilla, characteristic of this desert.

Some typical animals of this village are desert rabbit, hare California, cactus mouse, the swift fox, the coffee or desert wren, Northern roadrunner, the Mojave rattlesnake, the Chirrionera snake, the huico New Mexico or whiptail lizard, the spotted toad, the tiger salamander, Rat timber, the pallid bat, the coyote, the Mexican gray wolf, hooded skunk, the Wildcat, mule deer and the puma concolor.

The church of San Francisco de Asis is located in the municipal head is the most important monument of the town since its construction dates from 1710 and is still standing, the remains of the Temple of Guadalupe (located in the municipal cemetery before military prison) and the aqueduct are other important buildings of the colonial era.

The following table is to list the mayors and period: For the election of Deputies to Congress of Chihuahua and to General Congress, the municipality of San Francisco de Conchos is composed as follows: Local: Federal The population is predominantly Catholic, with a growing number of evangelical Christians (Protestants): Pentecostals, Baptists, Presbyterians and Methodists.