[1] In 1378 a hospice with a small oratory dedicated to San Giobbe or Saint Job attached was begun on this site by Giovanni Contarini, on land he owned near his house.

The oratory was replaced by the present church by Bernardino of Siena, with the financial backing of doge Cristoforo Moro in gratitude for Bernardino's prophecy that Moro would become doge - Cristoforo donated 10,000 ducats to the building works in 1471, three months before his death, and was buried in the church.

It was begun by Antonio Gambello and (when work began again in 1470) completed by the sculptor and architect Pietro Lombardo, with the latter designing the present altar arch and main door as well as much of the interior decoration.

Its altarpieces house works by Vivarini, Pietro Lombardo, Luca Della Robbia, Basaiti and Bordone, as well as Girolamo Savoldo's Il Presepio (1540).

The church also formerly held Giovanni Bellini's San Giobbe Altarpiece and Vittore Carpaccio's The Presentation of Jesus in the Temple: these works are now in the Gallerie dell'Accademia.