A church or oratory is cited to be present at the site since the 13th-century, when it was staffed by Augustinian priests from the nearby ancient convent of San Jacopo di Aquaviva.
The church facade awkwardly rises, tall and narrow, and is peppered with Mannerist, often contradictory, touches such as a rounded tympanum, a rectangular, scroll-like frame for an oval oculus.
The first altar to the right of the main door is dedicated to Saints Crespino and Crespiniano and a canvas attributed to school of Domenico Passignano.
Over the lateral door a canvas, depicts St Agnes with words: Mecum habeo angelum Domini, the painting is attributed to Felice Ficherelli.
The main altar was completed with marbles and pietra dura by Ferdinando Tacca (son of Pietro), a commission ordered by Lodovico da Verrazzano, governor of Livorno, whose heraldic symbol includes a red star.