[2] The church was completely reconstructed between 1498 and 1505 during the tenure of Grand Prior Fra Sebastiano Michiel, and the oldest known depiction of the building is in the 1500 View of Venice by Jacopo de' Barbari.

The building also came to be known as San Giovanni dei Furlani among locals after a community of Friulians that lived in its vicinity.

[1] The Grand Priory of Lombardy and Venice of the Sovereign Military Order of Malta, the successor to the Hospitallers, was reestablished in 1839.

It was designed by Cristoforo da Legname and it contains statues of saints sculpted by Bartolomeo Bergamasco [it].

[2] Several artworks can be found within the church, including Baptism of Christ by the studio of Giovanni Bellini and a copy of Titian's Saint John the Baptist.