San Lorenzello (Campanian: Sàntu Lurienzë) is a comune (municipality) in the Province of Benevento in the Italian region Campania, located northeast of Naples and about 25 kilometres (16 mi) northwest of Benevento.

San Lorenzello borders the following municipalities: Castelvenere, Cerreto Sannita, Cusano Mutri, Faicchio, Guardia Sanframondi, San Salvatore Telesino.

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