Santa Croce del Sannio is a comune (municipality) in the Province of Benevento in the Italian region Campania, located about 70 kilometres (43 mi) northeast of Naples and about 30 kilometres (19 mi) north of Benevento.

Santa Croce del Sannio borders the municipalities of Castelpagano, Cercemaggiore, Circello and Morcone.

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