San Lupo is the name of a hill town and comune in the province of Benevento, in the Campania region of southern Italy.

The town is located 60 km from the A1 highway, exit at Caserta, or is reachable by the Benevento-Caianello National Road.

The first settlement dates back to the period between the 10th and 11th century AD by Benedictine monks who were attracted to these lands and called them "San Lupo and Zosimus."

A major earthquake in 1456 caused serious damage, and forced the population to move upstream, where the village was rebuilt.

The survivors rebuilt it on the hill above, where homes had not suffered very much damage, due to the rocky nature of the soil.