San Salvatore Telesino (Campanian: U Casàle) is a comune (municipality) in the Province of Benevento in the Italian region Campania, located about 50 kilometres (31 mi) northeast of Naples and about 25 kilometres (16 mi) northwest of Benevento.

Sights include the remains of the ancient Telesia and of the former Rocca (castle), as well as the Abbey of San Salvatore.

The communal territory includes the remains (walls, amphitheater) of the ancient Telesia, a Samnite city.

A group of refugees from Telesia were sheltered by the monks of the Benedictine monastery of San Salvatore and given some terrain to build a new town, which took the name from the saint.

The castle was built in the 13th century by the count of Sanframondo, in a strategic position on the Valle Telesina (Telesia Valley).