San Marcos' climate enables the production of coffee and a large variety of tropical flowers and fruits.

San Marcos' Catholic Parish Church, in the middle of the town square, is a legacy of the Spaniard influence, as could be seen in its construction and designs.

Keiser University Latin American Campus is perhaps the only U.S. accredited institution of higher education granting degrees in Nicaragua and most of the region.

San Marcos is the birthplace of Clodomiro Picado Twight (1887–1944),[2] a Pasteur Institute scientist whose work on molds was a precursor to the formal discovery of penicillin.

He was only officially the 21st President of Nicaragua from 1 January 1937 to 1 May 1947 and from 21 May 1950 until his assassination on 29 September 1956, ruling for the rest of the time as an unelected military strongman.