San Mateo Tlapiltepec is a town and municipality in Oaxaca in south-western Mexico.

The municipality covers an area of 37 km2.

It is part of the Coixtlahuaca district in the Mixteca Region.

As of 2005, the municipality had a total population of 226.

[1] This article about a location in the Mexican state of Oaxaca is a stub.