San Miguel Tilquiapam is a town and municipality in Oaxaca in south-western Mexico.

The municipality covers an area of 39.55 km².

It is part of the Ocotlán District in the south of the Valles Centrales Region.

As of 2005, the municipality had a total population of 3,442.

This article about a location in the Mexican state of Oaxaca is a stub.